Genomic enhancers in cardiac development and disease
Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …
Modeling human cardiac arrhythmias: insights from zebrafish
Cardiac arrhythmia, or irregular heart rhythm, is associated with morbidity and mortality and
is described as one of the most important future public health challenges. Therefore …
is described as one of the most important future public health challenges. Therefore …
Patient-specific TBX5-G125R variant induces profound transcriptional deregulation and atrial dysfunction
AF van Ouwerkerk, FM Bosada, K van Duijvenboden… - Circulation, 2022 - Am Heart Assoc
Background: The pathogenic missense variant p. G125R in TBX5 (T-box transcription factor
5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of …
5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of …
Virtual and augmented reality: New tools for visualizing, analyzing, and communicating complex morphology
Virtual and augmented reality (VR/AR) are new technologies with the power to revolutionize
the study of morphology. Modern imaging approaches such as computed tomography, laser …
the study of morphology. Modern imaging approaches such as computed tomography, laser …
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development
In central nervous system vascular endothelial cells, signaling via the partially redundant
ligands WNT7A and WNT7B requires two co-activator proteins, GPR124 and RECK. WNT7A …
ligands WNT7A and WNT7B requires two co-activator proteins, GPR124 and RECK. WNT7A …
A Variant Noncoding Region Regulates Prrx1 and Predisposes to Atrial Arrhythmias
Rationale: Atrial fibrillation (AF) is the most common cardiac arrhythmia diagnosed in clinical
practice. Genome-wide association studies have identified AF-associated common variants …
practice. Genome-wide association studies have identified AF-associated common variants …
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene
Previously we showed the generation of a protein trap library made with the gene-break
transposon (GBT) in zebrafish (Danio rerio) that could be used to facilitate novel functional …
transposon (GBT) in zebrafish (Danio rerio) that could be used to facilitate novel functional …
Transcriptional regulation of the postnatal cardiac conduction system heterogeneity
Y Oh, R Abid, S Dababneh, M Bakr, T Aslani… - Nature …, 2024 - nature.com
The cardiac conduction system (CCS) is a network of specialized cardiomyocytes that
coordinates electrical impulse generation and propagation for synchronized heart …
coordinates electrical impulse generation and propagation for synchronized heart …
Inherited and acquired rhythm disturbances in sick sinus syndrome, Brugada syndrome, and atrial fibrillation: Lessons from preclinical modeling
Rhythm disturbances are life-threatening cardiovascular diseases, accounting for many
deaths annually worldwide. Abnormal electrical activity might arise in a structurally normal …
deaths annually worldwide. Abnormal electrical activity might arise in a structurally normal …
Molecular profiling of the cardiac conduction system: the Dawn of a new era
Abstract Purpose of Review Recent technological advances have led to an increased ability
to define the gene expression profile of the cardiac conduction system (CCS). Here, we …
to define the gene expression profile of the cardiac conduction system (CCS). Here, we …