Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Siberian forests are generally thought to have acted as an important carbon sink over recent
decades, but exposure to severe droughts and fire disturbances may have impacted their …

Inference about the causal structure that induces correlations between two traits can be
achieved by combining genetic associations with a mediation-based approach, as is done in …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

The gut microbiota has been typically viewed as an environmental factor for human health.
Twins are well suited for investigating the concordance of their gut microbiomes and …

Epigenetic alterations may provide important insights into gene-environment interaction in
inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation …

TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry
comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is …

The increased prevalence of obesity and related comorbidities is a major public health
problem. While genetic factors undoubtedly play a role in determining individual …

Epigenetic changes are caused by biochemical regulators of gene expression that can be
transferred across generations or through cell division. Epigenetic modifications can arise …