The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …

Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit
genetic information to our offspring as well as our own survival. To respond to these threats …

The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the
maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression …

Protein ubiquitination at sites of DNA double-strand breaks (DSBs) by RNF168 recruits
BRCA1 and 53BP1,, which are mediators of the homologous recombination and non …

Elucidation of endogenous cellular protein-protein interactions and their networks is most
desirable for biological studies. Here we report our study of endogenous human coregulator …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

When DNA double-strand breaks occur, the cell cycle stage has a major influence on the
choice of the repair pathway employed. Specifically, nonhomologous end joining is the …

Types of Cell Culture Media Animal cells can be cultured either using a completely natural
medium or an artificial/synthetic medium along with some natural products. Natural Media …

Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging
chemotherapeutic agents. To explore genetic resistance mechanisms, we performed …