Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

Osteoarthritis is a common age-related joint degenerative disease. Pain, swelling, brief
morning stiffness, and functional limitations are its main characteristics. There are still no …

Hypoxia, a low O2 tension, is a fundamental feature that occurs in physiological events as
well as pathophysiological conditions, especially mentioned for its role in the mechanism of …

In addition to controlling a switch to glycolytic metabolism and induction of erythropoiesis
and angiogenesis, hypoxia promotes the undifferentiated cell state in various stem and …

Hypoxia-inducible factor1 (HIF-1) is an essential transcription factor for cellular adaptation to
decreased oxygen availability. In normoxia the oxygen-sensitive α-subunit of HIF-1 is …

Oxygen depravation in mammals leads to the transcriptional induction of a host of target
genes to metabolically adapt to this deficiency, including erythropoietin and vascular …