Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson's disease

TA Alarcón, SM Presti-Silva, APT Simões… - Neural Regeneration …, 2023 - journals.lww.com
Parkinson's disease is the most common movement disorder, affecting about 1% of the
population over the age of 60 years. Parkinson's disease is characterized clinically by …

The neuroprotective effects of experience on cognitive functions: evidence from animal studies on the neurobiological bases of brain reserve

F Gelfo, L Mandolesi, L Serra, G Sorrentino… - Neuroscience, 2018 - Elsevier
Brain plasticity is the ability of the nervous system to change structurally and functionally in
response to experience. By sha** brain structure and function, experience leads to the …

Neuroprotective effect of crocin on substantia nigra in MPTP-induced Parkinson's disease model of mice

P Haeri, A Mohammadipour, Z Heidari… - Anatomical science …, 2019 - Springer
Parkinson's disease is caused by damage to substantia nigra dopaminergic neurons.
Factors such as oxidative stress, inflammatory factors, and acetylcholinesterase activity may …

Poly (I: C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment

X Zhao, R Mohammed, H Tran, M Erickson… - Brain, behavior, and …, 2021 - Elsevier
Environmental enrichment (EE) has been successfully implemented in human rehabilitation
settings. However, the mechanisms underlying its success are not understood. Incorporating …

Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients

Y Zhou, P Li, A Brantner, H Wang, X Shu, J Yang… - Scientific reports, 2017 - nature.com
Lepidium meyenii (Maca), originated from Peru, has been cultivated widely in China as a
popular health care food. However, the chemical and effective studies of Maca were less in …

Environmental enrichment cognitive neuroprotection in an experimental model of cerebral ischemia: biochemical and molecular aspects

LV Goncalves, AL Herlinger, TAA Ferreira… - Behavioural Brain …, 2018 - Elsevier
Stroke is considered a major cause of global morbidity. Currently, there are no effective
treatments for post-stroke cognitive impairment. Enriched environment (EE) has been …

Diosgenin attenuates lipopolysaccharide-induced Parkinson's disease by inhibiting the TLR/NF-κB pathway

B Li, P Xu, S Wu, Z Jiang, Z Huang… - Journal of Alzheimer's …, 2018 - content.iospress.com
Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by
loss of dopaminergic neurons in the substantia nigra. Diosgenin is a natural steroid saponin …

Neurobehavioral changes arising from early life dopamine signaling perturbations

LB Areal, RD Blakely - Neurochemistry international, 2020 - Elsevier
Dopamine (DA) signaling is critical to the modulation of multiple brain functions including
locomotion, reinforcement, attention and cognition. The literature provides strong evidence …

Enriched physical environment attenuates spatial and social memory impairments of aged socially isolated mice

L Wang, M Cao, T Pu, H Huang… - International Journal …, 2018 - academic.oup.com
Background Social isolation in the elderly is one of the principal health risks in an aging
society. Physical environmental enrichment is shown to improve sensory, cognitive, and …

Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP

SM Presti-Silva, AL Herlinger, C Martins-Silva… - Behavioural Brain …, 2023 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. The main therapeutic approach available nowadays relieves motor symptoms …