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Spider-venom peptides: structure, pharmacology, and potential for control of insect pests
Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have
been tuned over millions of years to target a wide range of receptors and ion channels in the …
been tuned over millions of years to target a wide range of receptors and ion channels in the …
[HTML][HTML] Spider-venom peptides as therapeutics
Spiders are the most successful venomous animals and the most abundant terrestrial
predators. Their remarkable success is due in large part to their ingenious exploitation of silk …
predators. Their remarkable success is due in large part to their ingenious exploitation of silk …
In Silico Approach for Predicting Toxicity of Peptides and Proteins
Background Over the past few decades, scientific research has been focused on develo**
peptide/protein-based therapies to treat various diseases. With the several advantages over …
peptide/protein-based therapies to treat various diseases. With the several advantages over …
ATSE: a peptide toxicity predictor by exploiting structural and evolutionary information based on graph neural network and attention mechanism
Motivation: Peptides have recently emerged as promising therapeutic agents against
various diseases. For both research and safety regulation purposes, it is of high importance …
various diseases. For both research and safety regulation purposes, it is of high importance …
[HTML][HTML] Spider-venom peptides as bioinsecticides
Over 10,000 arthropod species are currently considered to be pest organisms. They are
estimated to contribute to the destruction of~ 14% of the world's annual crop production and …
estimated to contribute to the destruction of~ 14% of the world's annual crop production and …
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads
Voltage-gated sodium (NaV) channels play a central role in the propagation of action
potentials in excitable cells in both humans and insects. Many venomous animals have …
potentials in excitable cells in both humans and insects. Many venomous animals have …
The World Spider Trait database: a centralized global open repository for curated data on spider traits
Spiders are a highly diversified group of arthropods and play an important role in terrestrial
ecosystems as ubiquitous predators, which makes them a suitable group to test a variety of …
ecosystems as ubiquitous predators, which makes them a suitable group to test a variety of …
Venomics: a new paradigm for natural products-based drug discovery
The remarkable potency and pharmacological diversity of animal venoms has made them
an increasingly valuable source of lead molecules for drug and insecticide discovery …
an increasingly valuable source of lead molecules for drug and insecticide discovery …
The venom optimization hypothesis revisited
Animal venoms are complex chemical mixtures that typically contain hundreds of proteins
and non-proteinaceous compounds, resulting in a potent weapon for prey immobilization …
and non-proteinaceous compounds, resulting in a potent weapon for prey immobilization …
Strategies for heterologous expression, synthesis, and purification of animal venom toxins
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …
which are responsible for the deleterious effect of envenomations. Across the animal …