Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

Evolution and emergence of Mycobacterium tuberculosis

M Orgeur, C Sous, J Madacki… - FEMS microbiology …, 2024 - academic.oup.com
Tuberculosis (TB) remains one of the deadliest infectious diseases in human history,
prevailing even in the 21st century. The causative agents of TB are represented by a group …

Cutaneous mycobacterial infections

C Franco-Paredes, LA Marcos… - Clinical microbiology …, 2018 - journals.asm.org
Humans encounter mycobacterial species due to their ubiquity in different environmental
niches. In many individuals, pathogenic mycobacterial species may breach our first-line …

A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

JCS Ngabonziza, C Loiseau, M Marceau… - Nature …, 2020 - nature.com
The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …

Host evasion and exploitation schemes of Mycobacterium tuberculosis

CJ Cambier, S Falkow, L Ramakrishnan - Cell, 2014 - cell.com
Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

V Makarov, B Lechartier, M Zhang, J Neres… - EMBO molecular …, 2014 - embopress.org
The benzothiazinone lead compound, BTZ 043, kills Mycobacterium tuberculosis by
inhibiting the essential flavo‐enzyme DprE1, decaprenylphosphoryl‐beta‐D‐ribose 2 …

[PDF][PDF] Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

M Asai, Y Li, SM Newton, BD Robertson… - FEMS Microbiology …, 2023 - academic.oup.com
Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …

The MycoBrowser portal: a comprehensive and manually annotated resource for mycobacterial genomes

A Kapopoulou, JM Lew, ST Cole - Tuberculosis, 2011 - Elsevier
In this paper, we present the MycoBrowser portal (http://mycobrowser. epfl. ch/), a resource
that provides both in silico generated and manually reviewed information within databases …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - journals.asm.org
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

HR Ramage, LE Connolly, JS Cox - PLoS genetics, 2009 - journals.plos.org
Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial
genomes, are unusually abundant in the major human pathogen Mycobacterium …