Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to
phospholipids,. To date, ferroptosis has been thought to be controlled only by the …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …

INTRODUCTION The ubiquitin-proteasome system is the major route through which the cell
achieves selective protein degradation. The E3 ubiquitin ligases are the major determinants …

Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer,
fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

The salt bridge is the strongest non-covalent interaction in nature and is known to participate
in protein folding, protein-protein interactions, and molecular recognition. However, the role …

Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate
invading pathogens and serves as a self-limiting mechanism of STING-induced interferon …