Bioactivities and structure–activity relationships of fusidic acid derivatives: a review

J Long, W Ji, D Zhang, Y Zhu, Y Bi - Frontiers in pharmacology, 2021 - frontiersin.org
Fusidic acid (FA) is a natural tetracyclic triterpene isolated from fungi, which is clinically used
for systemic and local staphylococcal infections, including methicillin-resistant …

Research, development and pharmacological activity of fusidic acid and its derivatives

X Huang, QK Shen, HY Guo, ZS Quan, X Li - Journal of Molecular Structure, 2023 - Elsevier
Fusidic acid is a tetracyclic triterpenoid isolated from fungi. Fusidic acid has a wide range of
pharmacological activities, including anti-inflammatory, antimalarial, antiparasitic and …

Synthesis of fusidic acid derivatives yields a potent antibiotic with an improved resistance profile

M Garcia Chavez, A Garcia, HY Lee… - ACS infectious …, 2021 - ACS Publications
Fusidic acid (FA) is a potent steroidal antibiotic that has been used in Europe for more than
60 years to treat a variety of infections caused by Gram-positive pathogens. Despite its …

3-amino-substituted analogues of fusidic acid as membrane-active antibacterial compounds

EV Salimova, OS Mozgovoj, SS Efimova… - Membranes, 2023 - mdpi.com
Fusidic acid (FA) is an antibiotic with high activity against Staphylococcus aureus; it has
been used in clinical practice since the 1960s. However, the narrow antimicrobial spectrum …

Discovery of fusidic acid derivatives as novel STING inhibitors for treatment of sepsis

J Long, T Ying, L Zhang, T Yu, J Wu, Y Liu, X Li… - European Journal of …, 2022 - Elsevier
Sepsis is often caused by systemic inflammatory responses. Stimulator of interferon genes
(STING) could be a promising treatment target for sepsis. In this study, we report the design …

Semisynthetic antimycobacterial C-3 silicate and C-3/C-21 ester derivatives of fusidic acid: pharmacological evaluation and stability studies in liver microsomes, rat …

M Njoroge, G Kaur, M Espinoza-Moraga… - ACS Infectious …, 2019 - ACS Publications
Fusidic acid (FA), a natural product fusidane triterpene-based antibiotic with unique
structural features, is active in vitro against Mycobacterium tuberculosis, the causative agent …

Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity

J Ni, M Guo, Y Cao, L Lei, K Liu, B Wang, F Lu… - European journal of …, 2019 - Elsevier
A series of novel fusidic acid (FA) derivatives were synthesized and screened for their in
vitro cytotoxicity against the Hela, U87, KBV and MKN45 cancer cell lines. Selected FA …

Imidazotetrazines as weighable diazomethane surrogates for esterifications and cyclopropanations

RL Svec, PJ Hergenrother - Angewandte Chemie, 2020 - Wiley Online Library
Diazomethane is one of the most versatile reagents in organic synthesis, but its utility is
limited by its hazardous nature. Although alternative methods exist to perform the unique …

Synthesis and biological activity of oximes, amines, and lactams of fusidane triterpenoids

EV Salimova, LV Parfenova - ChemistrySelect, 2021 - Wiley Online Library
The article presents the synthesis and study of the antimicrobial and antitumor activity of
fusidic acid derivatives containing oxime, amino substituents, and a caprolactam ring. The …

Indole derivatives of fusidane triterpenoids: synthesis and the antibacterial activity

EV Salimova, AA Magafurova, EV Tretyakova… - Chemistry of …, 2020 - Springer
New indole derivatives of fusidic acid were synthesized by using the Fischer reaction. The
obtained compounds were screened in vitro for antibacterial activity and were found to …