This review examines intermittent target search strategies, which combine phases of slow
motion, allowing the searcher to detect the target, and phases of fast motion during which …

Cellular DNA is continuously engaged in a molecular dance with many accessory proteins.
These proteins are responsible for orchestrating the storage, maintenance, and transfer of …

Many cellular functions rely on DNA-binding proteins finding and associating to specific sites
in the genome. Yet the mechanisms underlying the target search remain poorly understood …

The enormous size of mammalian genomes means that for a DNA-binding protein the
number of nonspecific, off-target sites vastly exceeds the number of specific, cognate sites …

Proteins that bind to specific sequences in long DNA molecules have to locate their target
sites amid myriad alternative sequences, yet they do so at remarkably rapid rates …

Chemical reactions make cells work only if the participating chemicals are delivered to
desired locations in a timely and precise fashion. Most research to date has focused on …

Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

When DNA-binding proteins search for their specific binding site on a DNA molecule they
alternate between linear 1-dimensional diffusion along the DNA molecule, mediated by …

Recognition and binding of specific sites on DNA by proteins is central for many cellular
functions such as transcription, replication, and recombination. In the search for its target …

We consider the first-passage problem for N identical independent particles that are initially
released uniformly in a finite domain Ω and then diffuse toward a reactive area Γ, which can …