The effects of polyphenols and other bioactives on human health

CG Fraga, KD Croft, DO Kennedy… - Food & function, 2019 - pubs.rsc.org
Although deficiencies in polyphenol intake do not result in specific deficiency diseases,
adequate intake of polyphenols could confer health benefits, especially with regard to …

Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

D Del Rio, A Rodriguez-Mateos… - Antioxidants & redox …, 2013 - liebertpub.com
Human intervention trials have provided evidence for protective effects of various (poly)
phenol-rich foods against chronic disease, including cardiovascular disease …

Lifestyle interventions for the prevention and treatment of hypertension

PL Valenzuela, P Carrera-Bastos, BG Gálvez… - Nature Reviews …, 2021 - nature.com
Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective

G Williamson, CD Kay, A Crozier - Comprehensive Reviews in …, 2018 - Wiley Online Library
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

[HTML][HTML] Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study …

HD Sesso, JAE Manson, AK Aragaki, PM Rist… - The American journal of …, 2022 - Elsevier
Background Cocoa extract is a source of flavanols that favorably influence vascular risk
factors in small and short-term trials, yet effects on clinical cardiovascular events are …

Bioavailability of bioactive food compounds: A challenging journey to bioefficacy

MJ Rein, M Renouf, C Cruz‐Hernandez… - British journal of …, 2013 - Wiley Online Library
Bioavailability is a key step in ensuring bioefficacy of bioactive food compounds or oral
drugs. Bioavailability is a complex process involving several different stages: liberation …

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

A Rodriguez-Mateos, D Vauzour, CG Krueger… - Archives of …, 2014 - Springer
There is substantial interest in the role of plant secondary metabolites as protective dietary
agents. In particular, the involvement of flavonoids and related compounds has become a …

Polyphenols and human health: prevention of disease and mechanisms of action

D Vauzour, A Rodriguez-Mateos, G Corona… - Nutrients, 2010 - mdpi.com
Polyphenols are found ubiquitously in plants and their regular consumption has been
associated with a reduced risk of a number of chronic diseases, including cancer …