[HTML][HTML] The microbiota–gut–brain axis in psychiatric disorders

A Góralczyk-Bińkowska, D Szmajda-Krygier… - International journal of …, 2022 - mdpi.com
Modulating the gut microbiome and its influence on human health is the subject of intense
research. The gut microbiota could be associated not only with gastroenterological diseases …

Mechanisms of blood–brain barrier protection by microbiota-derived short-chain fatty acids

E Fock, R Parnova - Cells, 2023 - mdpi.com
Impairment of the blood–brain barrier (BBB) integrity is implicated in the numerous
neurological disorders associated with neuroinflammation, neurodegeneration and aging. It …

Immunoregulatory role of the gut microbiota in inflammatory depression

P Liu, Z Liu, J Wang, J Wang, M Gao, Y Zhang… - Nature …, 2024 - nature.com
Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the
gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an …

Regulation of short-chain fatty acids in the immune system

XF Liu, JH Shao, YT Liao, LN Wang, Y Jia… - Frontiers in …, 2023 - frontiersin.org
A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …

The immunomodulatory functions of butyrate

MT Siddiqui, GAM Cresci - Journal of inflammation research, 2021 - Taylor & Francis
The gastrointestinal (GI) system contains many different types of immune cells, making it a
key immune organ system in the human body. In the last decade, our knowledge has …

[HTML][HTML] Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism

J He, P Zhang, L Shen, L Niu, Y Tan, L Chen… - International journal of …, 2020 - mdpi.com
Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …

Nutritional components in Western diet versus Mediterranean diet at the gut microbiota–immune system interplay. Implications for health and disease

C García-Montero, O Fraile-Martínez… - Nutrients, 2021 - mdpi.com
The most prevalent diseases of our time, non-communicable diseases (NCDs)(including
obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising …

[HTML][HTML] Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity

H Fan, S **a, J **ang, Y Li, MO Ross, SA Lim, F Yang… - Nature, 2023 - nature.com
Diet-derived nutrients are inextricably linked to human physiology by providing energy and
biosynthetic building blocks and by functioning as regulatory molecules. However, the …

[HTML][HTML] Unfermented β-fructan fibers fuel inflammation in select inflammatory bowel disease patients

HK Armstrong, M Bording-Jorgensen, DM Santer… - Gastroenterology, 2023 - Elsevier
Background & aims Inflammatory bowel diseases (IBD) are affected by dietary factors,
including nondigestible carbohydrates (fibers), which are fermented by colonic microbes …

[HTML][HTML] Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

M Akhtar, Y Chen, Z Ma, X Zhang, D Shi, JA Khan… - Animal nutrition, 2022 - Elsevier
Gut inflammation is a challenging concern in humans and animals, which disturbs normal
growth and leads to severe bowel diseases. Short chain fatty acids (SCFA) are the gut …