Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
YW Zhou, Y **e, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
“LONG COVID”—A hypothesis for understanding the biological basis and pharmacological treatment strategy
B Jarrott, R Head, KG Pringle… - Pharmacology …, 2022 - Wiley Online Library
Infection of humans with SARS‐CoV‐2 virus causes a disease known colloquially as
“COVID‐19” with symptoms ranging from asymptomatic to severe pneumonia. Initial …
“COVID‐19” with symptoms ranging from asymptomatic to severe pneumonia. Initial …
[HTML][HTML] SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We
report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most …
report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most …
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X **e, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …
great threat to global public health since 2020. Although the advance on vaccine …
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
Q Ning, D Wu, X Wang, D **, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …