Radiation therapy has curative or palliative potential in roughly half of all incident solid
tumours, and offers organ and function preservation in most cases. Unfortunately, early and …

Ovarian cancer is the seventh most common gynaecologic malignancy seen in women.
Majority of the patients with ovarian cancer are diagnosed at the advanced stage making …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

Purpose Genetic counseling is now routinely offered to individuals at high risk of carrying a
BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable …

Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …

BACKGROUND Previous studies have reported additional cancers associated with BRCA
mutations; however, the type, magnitude of risk, and sex differences remain to be clarified …

The standard initial management of epithelial ovarian cancer consists of surgical staging,
operative tumour debulking including total abdominal hysterectomy and bilateral sal**o …

Background Homologous recombination repair (HRR) enables fault-free repair of double-
stranded DNA breaks. HRR deficiency is predicted to occur in around half of high-grade …

BRCA1-and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is
characterized by an increased risk for female and male breast cancer, ovarian cancer …

Breast cancer is the most common malignancy among females. 5%–10% of breast cancer
cases are hereditary and are caused by pathogenic mutations in the considered reference …