BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …

The normal intervertebral disc (IVD) is a poorly innervated organ supplied only by sensory
(mainly nociceptive) and postganglionic sympathetic (vasomotor efferents) nerve fibers …

Elevated levels of TNF-α, IL-1β and a resultant increase in ADAMTS (a disintegrin-like and
metalloprotease with thrombospondin type I motifs) expression is seen during disc …

The extent of ageing in the musculoskeletal system during the life course affects the quality
and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed …

Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a
condition that represents a serious socio-economic burden. Deeper knowledge of the …

Although degeneration of the intervertebral disk has historically been described as a
misbalance between anabolic and catabolic factors, the role of inflammatory mediators has …

Low back pain (LBP) is the world's leading cause of disability and is increasing in
prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) …

We investigated TNF-α and IL-1β regulation of ADAMTS-4 expression in nucleus pulposus
(NP) cells and its role in aggrecan degradation. Real-time quantitative RT-PCR, Western …

Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-
modifying treatment. IVD degeneration is associated with instable mechanical loading in the …

Objective To investigate tumor necrosis factor α (TNFα) and interleukin‐1β (IL‐1β) regulation
of CCL3 expression in nucleus pulposus (NP) cells and in macrophage migration. Methods …