Replacement strategies for non-green dipolar aprotic solvents
Dipolar aprotic solvents (DMSO, DMF, DMAc, NMP, etc.) have been widely used in organic
synthesis and pharmaceutical research because of their remarkable polarities and …
synthesis and pharmaceutical research because of their remarkable polarities and …
Sustainable flow approaches to active pharmaceutical ingredients
The adoption of flow conditions has been the object of growing attention from both academia
and industry. The shift from batch to continuous-flow technology is very stimulating from a …
and industry. The shift from batch to continuous-flow technology is very stimulating from a …
Brønsted-acid sites promoted degradation of phthalate esters over MnO2: mineralization enhancement and aquatic toxicity assessment
Advanced oxidation processes (AOPs) are important technologies for aqueous organics
removal. Despite organic pollutants can be degraded via AOPs generally, high …
removal. Despite organic pollutants can be degraded via AOPs generally, high …
Quantitative sustainability assessment of flow chemistry–from simple metrics to holistic assessment
Flow chemistry has changed chemical process designs toward process intensification and is
generally considered as green methodology. In this connection, this perspective provides a …
generally considered as green methodology. In this connection, this perspective provides a …
Biomass waste-derived Pd–PiNe catalyst for the continuous-flow copper-free sonogashira reaction in a CPME–water azeotropic mixture
Herein, we report on the development of a waste minimization/valorization methodology
applied to the representative benchmark Sonogashira cross-coupling reaction performed in …
applied to the representative benchmark Sonogashira cross-coupling reaction performed in …
Classic vs. C–H functionalization strategies in the synthesis of APIs: a sustainability comparison
The landscape of organic synthesis has changed in the last two decades, especially in
areas such as pharmaceutical synthesis and large-scale industrial synthesis. The progress …
areas such as pharmaceutical synthesis and large-scale industrial synthesis. The progress …
Flow synthesis approaches to privileged scaffolds–recent routes reviewed for green and sustainable aspects
AI Alfano, M Brindisi, H Lange - Green Chemistry, 2021 - pubs.rsc.org
Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …
Waste-Minimized Continuous-Flow Synthesis of Oxindoles Exploiting a Polymer-Supported N Heterocyclic Palladium Carbene Complex in a CPME/Water Azeotrope
Herein, we report the development of an effective synthetic protocol for the synthesis of
oxindoles in flow based on a C (sp3)–H activation process promoted by a supported N …
oxindoles in flow based on a C (sp3)–H activation process promoted by a supported N …
Aerobic waste-minimized Pd-catalysed C–H alkenylation in GVL using a tube-in-tube heterogeneous flow reactor
Herein we report the design and application of a tube-in-tube packed-bed flow reactor for
the first time for the development of a heterogeneous palladium catalysed oxidative C–C …
the first time for the development of a heterogeneous palladium catalysed oxidative C–C …
Amorphous Fe0.8Mn0.2Ox-Catalyzed Four-Step Tandem Synthesis of Benzazoles from Alcohols and o-Substituted Anilines without Solvent
L Dong, J Qin, J Chen, M Chen, M Lv… - ACS Sustainable …, 2024 - ACS Publications
Benzazoles, as crucial intermediates, can be synthesized via a superior four-step tandem
catalytic process from benzyl alcohols and o-substituted anilines. However, the reported …
catalytic process from benzyl alcohols and o-substituted anilines. However, the reported …