COVID-19: Melatonin as a potential adjuvant treatment

R Zhang, X Wang, L Ni, X Di, B Ma, S Niu, C Liu… - Life sciences, 2020 - Elsevier
This article summarizes the likely benefits of melatonin in the attenuation of COVID-19
based on its putative pathogenesis. The recent outbreak of COVID-19 has become a …

Melatonin: A mitochondrial resident with a diverse skill set

RJ Reiter, R Sharma, S Rosales-Corral… - Life Sciences, 2022 - Elsevier
Melatonin is an ancient molecule that originated in bacteria. When these prokaryotes were
phagocytized by early eukaryotes, they eventually developed into mitochondria and …

[HTML][HTML] Melatonin as a potential approach to anxiety treatment

K Repova, T Baka, K Krajcirovicova, P Stanko… - International journal of …, 2022 - mdpi.com
Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …

Melatonin: both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light

DX Tan, RJ Reiter, S Zimmerman, R Hardeland - Biology, 2023 - mdpi.com
Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

Crosstalk between endoplasmic reticulum stress and anti-viral activities: a novel therapeutic target for COVID-19

A Banerjee, SJ Czinn, RJ Reiter, TG Blanchard - Life sciences, 2020 - Elsevier
The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic
with an urgent need for understanding the mechanisms and identifying a treatment. Viral …

Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders

LM Melhuish Beaupre, GM Brown… - Translational …, 2021 - nature.com
Melatonin is an ancient molecule that is evident in high concentrations in various tissues
throughout the body. It can be separated into two pools; one of which is synthesized by the …

Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm

RJ Reiter, R Sharma, MS Cucielo, DX Tan… - Cellular and Molecular …, 2023 - Springer
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Nutrients to improve mitochondrial function to reduce brain energy deficit and oxidative stress in migraine

M Fila, C Chojnacki, J Chojnacki, J Blasiak - Nutrients, 2021 - mdpi.com
The mechanisms of migraine pathogenesis are not completely clear, but 31P-nuclear
magnetic resonance studies revealed brain energy deficit in migraineurs. As glycolysis is the …

Aging-related ovarian failure and infertility: melatonin to the rescue

RJ Reiter, R Sharma, A Romero, W Manucha, DX Tan… - Antioxidants, 2023 - mdpi.com
Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases

VM Martín Giménez, N de Las Heras… - Frontiers in aging …, 2022 - frontiersin.org
The concept of “aging” is defined as the set of gradual and progressive changes in an
organism that leads to an increased risk of weakness, disease, and death. This process may …