Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Shape memory materials have emerged as an important class of materials in medicine due
to their ability to change shape in response to a specific stimulus, enabling the simplification …

Human tissues are sophisticated ensembles of many distinct cell types embedded in the
complex, but well-defined, structures of the extracellular matrix (ECM). Dynamic …

Porous membranes enable the partitioning of cellular microenvironments in vitro, while still
allowing physical and biochemical crosstalk between cells, a feature that is often necessary …

Improved methodologies for modeling cardiac disease phenotypes and accurately
screening the efficacy and toxicity of potential therapeutic compounds are actively being …

Shape memory polymers (SMPs) are a class of smart materials that change shape when
stimulated by environmental stimuli. Different from the shape memory effect at the macro …

In mammals, mechanics at multiple stages—nucleus to cell to ECM—underlie multiple
physiological and pathological functions from its development to reproduction to death …

Cardiac two-dimensional tissues were engineered using biomimetic micropatterns based on
the fibronectin-rich extracellular matrix (ECM) of the embryonic heart. The goal of this …

Over the past decade, advances in biomedical and tissue engineering technologies, such as
cell culture techniques, biomaterials, and biofabrication, have driven increasingly …

Cells sense and respond to a variety of physical cues from their surrounding
microenvironment, and these are interpreted through mechanotransductive processes to …