Determinants, maintenance, and function of organellar pH

SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Minimal out-of-equilibrium metabolism for synthetic cells: a membrane perspective

E Bailoni, M Partipilo, J Coenradij… - ACS Synthetic …, 2023 - ACS Publications
Life-like systems need to maintain a basal metabolism, which includes importing a variety of
building blocks required for macromolecule synthesis, exporting dead-end products, and …

Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na+/H+ antiporter

X Zhang, L Tang, J Nie, C Zhang, X Han, Q Li, L Qin… - Nature Plants, 2023 - nature.com
Salinity is one of the most severe abiotic stresses that adversely affect plant growth and
agricultural productivity. The plant Na+/H+ antiporter Salt Overly Sensitive 1 (SOS1) located …

Architecture and autoinhibitory mechanism of the plasma membrane Na+/H+ antiporter SOS1 in Arabidopsis

Y Wang, C Pan, Q Chen, Q **e, Y Gao, L He… - Nature …, 2023 - nature.com
Abstract Salt-overly-sensitive 1 (SOS1) is a unique electroneutral Na+/H+ antiporter at the
plasma membrane of higher plants and plays a central role in resisting salt stress. SOS1 is …

Structure and mechanism of the human NHE1-CHP1 complex

Y Dong, Y Gao, A Ilie, DS Kim, A Boucher, B Li… - Nature …, 2021 - nature.com
Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …

[HTML][HTML] Structure and electromechanical coupling of a voltage-gated Na+/H+ exchanger

H Yeo, V Mehta, A Gulati, D Drew - Nature, 2023 - nature.com
Voltage-sensing domains control the activation of voltage-gated ion channels, with a few
exceptions. One such exception is the sperm-specific Na+/H+ exchanger SLC9C1, which is …

Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2

R Matsuoka, R Fudim, S Jung, C Zhang… - Nature Structural & …, 2022 - nature.com
Abstract The Na+/H+ exchanger SLC9B2, also known as NHA2, correlates with the long-
sought-after Na+/Li+ exchanger linked to the pathogenesis of diabetes mellitus and …

Structures of a sperm-specific solute carrier gated by voltage and cAMP

V Kalienkova, MF Peter, J Rheinberger, C Paulino - Nature, 2023 - nature.com
The newly characterized sperm-specific Na+/H+ exchanger stands out by its unique tripartite
domain composition,. It unites a classical solute carrier unit with regulatory domains usually …

Adaptation of anaerobic digestion microbial communities to high ammonium levels: insights from strain-resolved metagenomics

L Bucci, G Ghiotto, G Zampieri, R Raga… - Environmental …, 2023 - ACS Publications
Ammonia release from proteinaceous feedstocks represents the main inhibitor of the
anaerobic digestion (AD) process, which can result in a decreased biomethane yield or …

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9

I Winkelmann, R Matsuoka, PF Meier, D Shutin… - The EMBO …, 2020 - embopress.org
Abstract Na+/H+ exchangers (NHEs) are ancient membrane‐bound nanomachines that
work to regulate intracellular pH, sodium levels and cell volume. NHE activities contribute to …