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[HTML][HTML] Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: recent developments in positron emission tomography
B Janssen, DJ Vugts, U Funke, GT Molenaar… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …
Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: A patent review (2010–2015; part 1)
TH Kim, AN Pae - Expert Opinion on Therapeutic Patents, 2016 - Taylor & Francis
Introduction: The translocator protein (TSPO) is an emerging target in diverse
neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) …
neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) …
In vivo detection of age-and disease-related increases in neuroinflammation by 18F-GE180 TSPO microPET imaging in wild-type and Alzheimer's transgenic mice
B Liu, KX Le, MA Park, S Wang, AP Belanger… - Journal of …, 2015 - jneurosci.org
Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation
appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator …
appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator …
PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections
S Shah, S Sinharay, R Patel, J Solomon, JH Lee… - Proceedings of the …, 2022 - pnas.org
Ebola virus (EBOV) disease is characterized by lymphopenia, breach in vascular integrity,
cytokine storm, and multiorgan failure. The pathophysiology of organ involvement, however …
cytokine storm, and multiorgan failure. The pathophysiology of organ involvement, however …
Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging
JS Takkinen, FR Lopez-Picon… - Journal of Cerebral …, 2017 - journals.sagepub.com
Preclinical animal model studies of brain energy metabolism and neuroinflammation in
Alzheimer's disease have produced conflicting results, hampering both the elucidation of the …
Alzheimer's disease have produced conflicting results, hampering both the elucidation of the …
TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR …
Huntington's disease (HD) is an inherited neurodegenerative disorder that has no cure. HD
therapeutic development would benefit from a non-invasive translatable biomarker to track …
therapeutic development would benefit from a non-invasive translatable biomarker to track …
In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting …
Purpose To evaluate the feasibility and sensitivity of multimodality PET/CT and MRI imaging
for non-invasive characterization of brain microglial/macrophage activation occurring during …
for non-invasive characterization of brain microglial/macrophage activation occurring during …
Regulation of mitochondrial, cellular, and organismal functions by TSPO
M Gavish, L Veenman - Advances in pharmacology, 2018 - Elsevier
In 1999, the enigma of the 18 kDa mitochondrial translocator protein (TSPO), also known as
the peripheral-type benzodiazepine receptor, was the seeming disparity of the many …
the peripheral-type benzodiazepine receptor, was the seeming disparity of the many …
Discovery of a fluorinated 4‐oxo‐quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2
R Slavik, A Müller Herde, A Haider… - Journal of …, 2016 - Wiley Online Library
The cannabinoid receptor type 2 (CB 2) is part of the endocannabinoid system and has
gained growing attention in recent years because of its important role in neuroinflammatory …
gained growing attention in recent years because of its important role in neuroinflammatory …
Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with 18F-DPA-714 and micro-PET/CT
Purpose To evaluate the feasibility and sensitivity of 18 F-DPA-714 for the study of microglial
activation in the brain and spinal cord of transgenic SOD1 G93A mice using high-resolution …
activation in the brain and spinal cord of transgenic SOD1 G93A mice using high-resolution …