Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …

Cone-rod dystrophies (CORDs) are a heterogeneous group of inherited retinopathies (IRDs)
with more than 30 already known disease-causing genes. Uncertain phenotypes and …

Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …

The function, trafficking and synaptic signaling of AMPA receptors are tightly regulated by
phosphorylation. Ca2+/calmodulin-dependent kinase II (CaMKII) phosphorylates the GluA1 …

Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

An estimated 15–50% of the population experiences pain at any given time, at great
personal and societal cost. Pain is the most common reason patients seek medical attention …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

Synaptic scaling stabilizes neuronal firing through the homeostatic regulation of
postsynaptic strength, but the mechanisms by which chronic changes in activity lead to …