Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …

Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …

In recent decades, very few new psychiatric drugs have entered the market. Thus,
improvement in the use of antidepressant and antipsychotic therapy has to focus mainly on …

Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

There are marked sex differences in the prevalence, phenotypic presentation and treatment
response for major depression. While genome-wide association studies (GWAS) adjust for …

Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake,
although still leads to discussions as to its clinical use. Psychiatry constitutes a field where …

Adverse drug reactions (ADR) remain the major problems in healthcare. Most severe ADR
are unpredictable, dose-independent and termed as type B idiosyncratic reactions. Recent …

Develo** a more comprehensive understanding of the physiological underpinnings of
mental illness, precision medicine has the potential to revolutionize psychiatric care. With …

Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for
antidepressant metabolism and polymorphisms of these genes have been determined to …