RNA interference (RNAi) is a powerful approach for reducing expression of endogenously
expressed proteins. It is widely used for biological applications and is being harnessed to …

Vive la différence: biogenesis and evolution of microRNAs in plants and animals | Genome
Biology Skip to main content Advertisement Springer Nature Link Account Menu Find a journal …

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

To use microRNAs to downregulate mRNA targets, cells must first process these∼ 22 nt
RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important …

Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …

A well-defined mechanism governs the maturation of most microRNAs (miRNAs) in animals,
via stepwise cleavage of precursor hairpin transcripts by the Drosha and Dicer RNase III …

MicroRNAs (miRNAs) are major post‐transcriptional regulators of gene expression. They
base pair with the complementary target mRNA at the 3′ UTR and modulate cellular …

Atypical miRNA substrates do not fit criteria often used to annotate canonical miRNAs, and
can escape the notice of miRNA genefinders. Recent analyses expanded the catalogs of …

Since the initial annotation of miRNAs from cloned short RNAs by the Ambros, Tuschl, and
Bartel groups in 2001, more than a hundred studies have sought to identify additional …

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression in animals
and in plants. In recent years, miRNAs have been shown to be important biological …