[HTML][HTML] Normal and glaucomatous outflow regulation
Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …
[HTML][HTML] Structural framework to address variant-gene relationship in primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a complex, multifactorial disease leading to
progressive optic neuropathy and irreversible vision loss. Genome-Wide Association …
progressive optic neuropathy and irreversible vision loss. Genome-Wide Association …
The relationship between outflow resistance and trabecular meshwork stiffness in mice
K Wang, G Li, AT Read, I Navarro, AK Mitra… - Scientific reports, 2018 - nature.com
It has been suggested that common mechanisms may underlie the pathogenesis of primary
open-angle glaucoma (POAG) and steroid-induced glaucoma (SIG). The biomechanical …
open-angle glaucoma (POAG) and steroid-induced glaucoma (SIG). The biomechanical …
Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior
Ocular hypertension is a causal risk-factor to develo** glaucoma. This is associated with
stiffening of the trabecular meshwork (TM), the primary site of resistance to aqueous-humor …
stiffening of the trabecular meshwork (TM), the primary site of resistance to aqueous-humor …
[HTML][HTML] Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone
Although biomechanical changes of the trabecular meshwork (TM) are important to the
pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a …
pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a …
Lysophosphatidic acid and IL-6 trans-signaling interact via YAP/TAZ and STAT3 signaling pathways in human trabecular meshwork cells
Purpose: Lysophosphatidic acid (LPA) and soluble interleukin-6 receptor (sIL6R) are
elevated in primary open angle glaucoma (POAG). LPA and IL6 modulate in response to …
elevated in primary open angle glaucoma (POAG). LPA and IL6 modulate in response to …
Glucocorticoid-induced cell-derived matrix modulates transforming growth factor β2 signaling in human trabecular meshwork cells
Aberrant remodeling of trabecular meshwork (TM) extracellular matrix (ECM) may induce
ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via …
ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via …
Crosslinked extracellular matrix stiffens human trabecular meshwork cells via dysregulating β-catenin and YAP/TAZ signaling pathways
F Yemanyi, J Vranka… - … ophthalmology & visual …, 2020 - iovs.arvojournals.org
Purpose: The purpose of this study was to determine whether genipin-induced crosslinked
cell-derived matrix (XCDM) precipitates fibrotic phenotypes in human trabecular meshwork …
cell-derived matrix (XCDM) precipitates fibrotic phenotypes in human trabecular meshwork …
[HTML][HTML] Cell atlas of trabecular meshwork in glaucomatous non-human primates and DEGs related to tissue contract based on single-cell transcriptomics
X Jia, J Wu, X Chen, S Hou, Y Li, L Zhao, Y Zhu, Z Li… - Iscience, 2023 - cell.com
As the major channel of aqueous humor outflow, dysfunction of trabecular meshwork (TM)
can lead to intraocular pressure elevating, which can trigger primary open-angle glaucoma …
can lead to intraocular pressure elevating, which can trigger primary open-angle glaucoma …
Development of Microcystoid Macular Degeneration in the Retina of Nonhuman Primates: Time-Course and Associated Pathologies
TCM Lavery, CA Rasmussen, AW Katz… - Current Eye …, 2025 - Taylor & Francis
Purpose Microcystoid macular degeneration (MMD) is a condition where cystoid vacuoles
develop within the inner nuclear layer of the retina in humans in a variety of disorders. Here …
develop within the inner nuclear layer of the retina in humans in a variety of disorders. Here …