Programmed cell death in spinal cord injury pathogenesis and therapy

Z Shi, S Yuan, L Shi, J Li, G Ning, X Kong… - Cell …, 2021 - Wiley Online Library
Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes
including cell death. In recent years, programmed cell death (PCD) is considered to be a …

Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …

M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways

J Wang, H Wu, Y Peng, Y Zhao, Y Qin, Y Zhang… - Journal of …, 2021 - Springer
Refractory diabetic wounds can cause persistent inflammation and delayed healing due to
hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs …

Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p …

R Shi, Y **, W Hu, W Lian, C Cao… - … of Physiology-Cell …, 2020 - journals.physiology.org
More and more evidence advises that circular RNAs (circRNAs) function critically in
regulating different disease microenvironments. Our previous study found that …

Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration

R Li, D Li, C Wu, L Ye, Y Wu, Y Yuan, S Yang… - …, 2020 - pmc.ncbi.nlm.nih.gov
Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris degradation and
clearance following peripheral nerve injury (PNI). Nerve growth factor (NGF) plays an …

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress

K Zhou, Z Zheng, Y Li, W Han, J Zhang, Y Mao… - …, 2020 - pmc.ncbi.nlm.nih.gov
Background and Aim: Increasing evidence suggests that spinal cord injury (SCI)-induced
defects in autophagic flux may contribute to an impaired ability for neurological repair …

Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice

W Jiang, M Li, F He, S Zhou, L Zhu - Journal of neuroinflammation, 2017 - Springer
Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …

Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury

Y Wu, J **ong, Z He, Y Yuan, B Wang, J Xu… - Acta Pharmacologica …, 2022 - nature.com
Spinal cord injury (SCI) is one kind of severe trauma for central nervous system. Myelin
debris clearance and axon regeneration are essential for nerve regeneration after SCI …

Mesenchymal stromal cell-derived extracellular vesicles in the treatment of diabetic foot ulcers: application and challenges

T An, Y Chen, Y Tu, P Lin - Stem cell reviews and reports, 2021 - Springer
Diabetic foot ischemia and ulcer (DFU) persists as a serious diabetes mellitus complication
in spite of increased understanding of the pathophysiology and the cellular and molecular …

Metformin promotes axon regeneration after spinal cord injury through inhibiting oxidative stress and stabilizing microtubule

H Wang, Z Zheng, W Han, Y Yuan, Y Li… - Oxidative medicine …, 2020 - Wiley Online Library
Spinal cord injury (SCI) is a devastating disease that may lead to lifelong disability. Thus,
seeking for valid drugs that are beneficial to promoting axonal regrowth and elongation after …