RNA m6A methylation across the transcriptome
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
A comprehensive review of m6A/m6Am RNA methyltransferase structures
S Oerum, V Meynier, M Catala, C Tisné - Nucleic acids research, 2021 - academic.oup.com
Gene expression is regulated at many levels including co-or post-transcriptionally, where
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
Epigenetic modification of m6A regulator proteins in cancer
Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
Y Chen, Y Lin, Y Shu, J He, W Gao - Molecular cancer, 2020 - Springer
As a critical internal RNA modification in higher eukaryotes, N 6-methyladenosine (m 6 A)
has become the hotspot of epigenetics research in recent years. Extensive studies on …
has become the hotspot of epigenetics research in recent years. Extensive studies on …
Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions
X Wang, R Ma, X Zhang, L Cui, Y Ding, W Shi, C Guo… - Molecular cancer, 2021 - Springer
Abstract N 6-methyladenosine (m 6 A) is a prevalent internal modification in eukaryotic
RNAs regulated by the so-called “writers”,“erasers”, and “readers”. m 6 A has been …
RNAs regulated by the so-called “writers”,“erasers”, and “readers”. m 6 A has been …