Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Signal peptides (SPs) are short amino acid sequences that control protein secretion and
translocation in all living organisms. SPs can be predicted from sequence data, but existing …

Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative
bacteria. Minute amounts of LPS released from infecting pathogens can initiate potent innate …

Traditional vaccines, based on the administration of killed or attenuated microorganisms,
have proven to be among the most effective methods for disease prevention. Safety issues …

Streptomyces bacteria are ubiquitous in soil, conferring the characteristic earthy smell, and
they have an important ecological role in the turnover of organic material. More recently, a …

Over the past decade it has become clear that lactobacilli and other probiotic and
commensal organisms can interact with mucosal immune cells or epithelial cells lining the …

Bacterial lipoproteins are a set of membrane proteins with many different functions. Due to
this broad-ranging functionality, these proteins have a considerable significance in many …

Bacterial lipoproteins are synthesized as precursors in the cytoplasm and processed into
mature forms on the cytoplasmic membrane. A lipid moiety attached to the N terminus …

Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT)
through many mechanisms, which include pathogen inhibition, maintenance of microbial …