Role of LDH in tumor glycolysis: regulation of LDHA by small molecules for cancer therapeutics
D Sharma, M Singh, R Rani - Seminars in cancer biology, 2022 - Elsevier
Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …
Targeting mitochondrial metabolic reprogramming as a potential approach for cancer therapy
L Zhang, Y Wei, S Yuan, L Sun - International Journal of Molecular …, 2023 - mdpi.com
Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are
important components of tumor metabolic reprogramming. Mitochondria have gradually …
important components of tumor metabolic reprogramming. Mitochondria have gradually …
Mitochondrial transfer between cell crosstalk-an emerging role in mitochondrial quality control
Y Liu, T Fu, G Li, B Li, G Luo, N Li, Q Geng - Ageing Research Reviews, 2023 - Elsevier
Intercellular signaling and component conduction are essential for multicellular organisms'
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …
[HTML][HTML] A potential “anti-Warburg effect” in circulating tumor cell-mediated metastatic progression?
Z Jiang, J He, B Zhang, L Wang, C Long… - Aging and …, 2023 - pmc.ncbi.nlm.nih.gov
Metabolic reprogramming is a defining hallmark of cancer metastasis, warranting thorough
exploration. The tumor-promoting function of the" Warburg Effect", marked by escalated …
exploration. The tumor-promoting function of the" Warburg Effect", marked by escalated …
TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis
Y Wang, Y Wang, W Liu, L Ding, X Zhang… - Cell Death & …, 2023 - nature.com
Mitochondrial function and homeostasis are critical to the proliferation of lung cancer cells. T-
cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the …
cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the …
[HTML][HTML] Extracellular flux assay (Seahorse assay): Diverse applications in metabolic research across biological disciplines
I Yoo, I Ahn, J Lee, N Lee - Molecules and Cells, 2024 - Elsevier
Metabolic networks are fundamental to cellular processes, driving energy production,
biosynthesis, redox regulation, and cellular signaling. Recent advancements in metabolic …
biosynthesis, redox regulation, and cellular signaling. Recent advancements in metabolic …