The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

The discrepancy between organ need and organ availability represents one of the major
limitations in the field of transplantation. One possible solution to this problem is …

Decay-accelerating factor ([DAF] CD55) is a glycosylphosphatidylinositol-anchored
membrane inhibitor of complement with broad clinical relevance. Here, we establish an …

Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …

Xenotransplantation using pig organs could solve the significant increasing shortage of
donor organs for allotransplantation. In the last two decades, major progress has been made …

Progress in pig organ xenotransplantation has been made largely through (1) genetic
engineering of the organ-source pig to protect its tissues from the human innate immune …

OBJECTIVES: Transplantation is limited by a lack of human organ donors. Organs derived
from animals, most likely the pig, represent a potential solution to this problem. For the heart …

Background. Transgenic expression of human complement regulatory proteins reduces the
frequency of hyperacute rejection (HAR) in Gal-positive cardiac xenotransplantation. In this …

Background: The functional response and immunobiology of primarily non‐vascularized
islet cell xenografts remain poorly defined in non‐human primates. Methods: We …

Abstract Purpose of Review The first successful pig to human cardiac xenotransplantation in
January 2022 represented a major step forward in the fields of heart failure, immunology …