A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …

Chemical exchange saturation transfer (CEST) imaging is a novel contrast mechanism,
relying on the exchange between mobile protons in amide (-NH), amine (-NH 2) and …

In multiple sclerosis (MS), gray matter (GM) atrophy progresses in a non-random manner,
possibly in regions with a high distribution of specific neurotransmitters involved in several …

Access to metabolic information in vivo using magnetic resonance (MR) technologies has
generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI) …

Glutamate is the primary excitatory neurotransmitter in the mammalian central nervous
system. As such, its proper regulation is essential to the healthy function of the human brain …

Purpose Chemical exchange saturation transfer (CEST) signals at 3 ppm acquired with high
irradiation powers, termed GluCEST, have been suggested as an indicator of glutamate in …

Purpose To develop a CEST quantification model to map glutamate concentration in the
mouse brain at 11.7 T, overcoming the limitations of conventional glutamate‐weighted CEST …

Background: Multiple sclerosis (MS), a disabling demyelinating disease of the central
nervous system, is associated with cognitive impairment, spasticity, and fatigue. There are …

Introduction Hippocampal glutamate (Glu) dysfunction is a pertinent indicator of
neurodegeneration, yet map** typical age-related changes in Glu has been challenging …

Astrocytes and oligodendrocytes play essential roles in regulating neural signal transduction
along neural circuits in CNS. The perfect coordination of neuron/astrocyte and neuron …