Blue-light receptors for optogenetics

A Losi, KH Gardner, A Möglich - Chemical reviews, 2018 - ACS Publications
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

[HTML][HTML] Light-oxygen-voltage (LOV)-sensing domains: activation mechanism and optogenetic stimulation

A Flores-Ibarra, RNA Maia, B Olasz, JR Church… - Journal of molecular …, 2024 - Elsevier
The light-oxygen-voltage (LOV) domains of phototropins emerged as essential constituents
of light-sensitive proteins, hel** initiate blue light-triggered responses. Moreover, these …

Light-switchable transcription factors obtained by direct screening in mammalian cells

L Zhu, HM McNamara, JE Toettcher - Nature communications, 2023 - nature.com
Optogenetic tools can provide fine spatial and temporal control over many biological
processes. Yet the development of new light-switchable protein variants remains …

Light-regulated gene expression in Bacteria: Fundamentals, advances, and perspectives

R Ohlendorf, A Möglich - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Numerous photoreceptors and genetic circuits emerged over the past two decades and now
enable the light-dependent ie, optogenetic, regulation of gene expression in bacteria …

Individual and shared digital repertoires–older adults managing digital services

R Hänninen, L Pajula, V Korpela… - … Communication & Society, 2023 - Taylor & Francis
The rise of public and other non-recreational digital services is based on the idea of catering
to the daily needs of the citizens cost-efficiently and with ease. Previous research has …

Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling

E Multamäki, R Nanekar, D Morozov… - Nature …, 2021 - nature.com
Bacterial phytochrome photoreceptors usually belong to two-component signaling systems
which transmit environmental stimuli to a response regulator through a histidine kinase …

Engineering of temperature-and light-switchable Cas9 variants

F Richter, I Fonfara, B Bouazza… - Nucleic acids …, 2013 - academic.oup.com
Sensory photoreceptors have enabled non-invasive and spatiotemporal control of numerous
biological processes. Photoreceptor engineering has expanded the repertoire beyond …

A blue light receptor that mediates RNA binding and translational regulation

AM Weber, J Kaiser, T Ziegler, S Pilsl, C Renzl… - Nature chemical …, 2019 - nature.com
Sensory photoreceptor proteins underpin light-dependent adaptations in nature and enable
the optogenetic control of organismal behavior and physiology. We identified the bacterial …

Signal transduction in photoreceptor histidine kinases

A Möglich - Protein science, 2019 - Wiley Online Library
Two‐component systems (TCS) constitute the predominant means by which prokaryotes
read out and adapt to their environment. Canonical TCSs comprise a sensor histidine kinase …

Highlighter: An optogenetic system for high-resolution gene expression control in plants

B Larsen, R Hofmann, IS Camacho, RW Clarke… - PLoS …, 2023 - journals.plos.org
Optogenetic actuators have revolutionized the resolution at which biological processes can
be controlled. In plants, deployment of optogenetics is challenging due to the need for these …