The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …

Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming
incidence rate and a huge burden on health care providers. DM is characterized by the …

Radioresistance is a principal culprit for the failure of radiotherapy in hepatocellular
carcinoma (HCC). Insights on the regulation genes of radioresistance and underlying …

Background Natural food products have been used for combating human diseases for
thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones …

Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries
in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of …

The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …

Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the
best understood signal transduction cascades. Almost 40 cytokine receptors signal through …

Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively
regulates all cell types involved in the initiation, propagation, and resolution of inflammation …

The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first
described as inhibitors of cytokine signalling. While their actions clearly now extend to other …