The proteasome degrades most cellular proteins in a controlled and tightly regulated
manner and thereby controls many processes, including cell cycle, transcription, signalling …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …

Aging has been associated with a progressive decline of proteostasis, but how this process
affects proteome composition remains largely unexplored. Here, we profiled more than …

The ubiquitin proteasome system maintains protein homeostasis by regulating the
breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The …

The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …

Ageing is driven by a loss of cellular integrity. Given the major role of ubiquitin modifications
in cell function, here we assess the link between ubiquitination and ageing by quantifying …

Forkhead box O (FOXO) transcription factors are involved in the regulation of the cell cycle,
apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell …