International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and …

HI Michelena, A Della Corte… - European Journal of …, 2021 - academic.oup.com
Abstract This International Consensus Classification and Nomenclature for the congenital
bicuspid aortic valve condition recognizes 3 types of bicuspid valves: 1. The fused type (right …

The role of imaging of flow patterns by 4D flow MRI in aortic stenosis

J Garcia, AJ Barker, M Markl - JACC: Cardiovascular Imaging, 2019 - jacc.org
Aortic valve stenosis (AS) is the most prevalent valvular heart disease in developed
countries and is associated with the development of severe secondary complications such …

Transcatheter aortic valve implantation represents an anti-inflammatory therapy via reduction of shear stress–induced, piezo-1–mediated monocyte activation

S Baratchi, MTK Zaldivia, M Wallert, J Loseff-Silver… - Circulation, 2020 - Am Heart Assoc
Background: Aortic valve stenosis is an increasingly prevalent degenerative and
inflammatory disease. Transcatheter aortic valve implantation (TAVI) has revolutionized its …

Association of regional wall shear stress and progressive ascending aorta dilation in bicuspid aortic valve

G Soulat, MB Scott, BD Allen, R Avery, RO Bonow… - Cardiovascular …, 2022 - jacc.org
Objectives The aim of this study was to evaluate the role of wall shear stress (WSS) as a
predictor of ascending aorta (AAo) growth at 5 years or greater follow-up. Background Aortic …

Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy

E Bollache, DG Guzzardi, S Sattari, KE Olsen… - The Journal of thoracic …, 2018 - Elsevier
Objectives The objectives of this study were to investigate an association between the
magnitude of flow-mediated aortic wall shear stress (WSS) and medial wall histopathology …

Mechanisms of Aortic Dilation in Patients With Bicuspid Aortic Valve: JACC State-of-the-Art Review

JF Rodríguez-Palomares, L Dux-Santoy… - Journal of the American …, 2023 - jacc.org
Bicuspid aortic valve is the most common congenital heart disease and exposes patients to
an increased risk of aortic dilation and dissection. Aortic dilation is a slow, silent process …

4D Flow with MRI

G Soulat, P McCarthy, M Markl - Annual review of biomedical …, 2020 - annualreviews.org
Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation
of patients with cardiac and vascular diseases. Since its introduction in the late 1980s …

Wall shear stress predicts media degeneration and biomechanical changes in thoracic aorta

M Kiema, JK Sarin, SP Kauhanen, J Torniainen… - Frontiers in …, 2022 - frontiersin.org
Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is
progressively dilating due to the weakening of the aortic wall. Predicting and preventing …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

Shear stress and aortic strain associations with biomarkers of ascending thoracic aortic aneurysm

S Pasta, V Agnese, A Gallo, F Cosentino… - The Annals of thoracic …, 2020 - Elsevier
Background This study aims to investigate the association of wall shear stress (WSS) and
aortic strain with circulating biomarkers including matrix metalloproteinases (MMP), tissue …