Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …

Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella.
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …

Over the course of evolution, the centrosome function has been conserved in most
eukaryotes, but its core architecture has evolved differently in some clades, with the …

Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated
by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we …

Nephronophthisis (NPH) is an autosomal-recessive ciliopathy representing one of the most
frequent causes of kidney failure in childhood characterized by a broad clinical and genetic …

Proper placental development in early pregnancy ensures a positive outcome later on. The
developmental relationship between the placenta and embryonic organs, such as the heart …

Distal appendages (DAPs) are vital in cilia formation, mediating vesicular and ciliary docking
to the plasma membrane during early ciliogenesis. Although numerous DAP proteins …

Centrosomes are the main microtubule-organizing centres, playing essential roles in the
organization of the cytoskeleton during interphase, and in the mitotic spindle, which controls …

In metazoa, cilia assembly is a cellular process that starts with centriole to basal body
maturation, migration to the cell surface, and docking to the plasma membrane. Basal body …