Towards a future where Alzheimer's disease pathology is stopped before the onset of dementia

WM van der Flier, ME de Vugt, EMA Smets, M Blom… - Nature aging, 2023 - nature.com
Alzheimer's disease (AD) is a major healthcare challenge with no curative treatment at
present. To address this challenge, we need a paradigm shift, where we focus on pre …

Diagnosis and management of dementia

Z Arvanitakis, RC Shah, DA Bennett - Jama, 2019 - jamanetwork.com
Importance Worldwide, 47 million people live with dementia and, by 2050, the number is
expected to increase to 131 million. Observations Dementia is an acquired loss of cognition …

The worldwide costs of dementia in 2019

A Wimo, K Seeher, R Cataldi, E Cyhlarova… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Dementia is a leading cause of death and disability globally. Estimating total
societal costs demonstrates the wide impact of dementia and its main direct and indirect …

[HTML][HTML] Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort

P Liu, L Wu, G Peng, Y Han, R Tang, J Ge… - Brain, behavior, and …, 2019 - Elsevier
Abstract Objective (Background): Alzheimer's disease (AD), clinically characterized by the
progressive neurodegenerative condition and cognitive impairment, is one of the main …

[หนังสือ][B] The new psychology of health: Unlocking the social cure

C Haslam, J Jetten, T Cruwys, G Dingle, SA Haslam - 2018 - taylorfrancis.com
British Psychology Society Textbook of the Year 2020 Why do people who are more socially
connected live longer and have better health than those who are socially isolated? Why are …

The cost of Alzheimer's disease in China and re‐estimation of costs worldwide

J Jia, C Wei, S Chen, F Li, YI Tang, W Qin… - Alzheimer's & …, 2018 - Wiley Online Library
Introduction The socioeconomic costs of Alzheimer's disease (AD) in China and its impact
on global economic burden remain uncertain. Methods We collected data from 3098 …

A comparative analysis of machine learning algorithms to predict Alzheimer's disease

M Bari Antor, AHMS Jamil, M Mamtaz… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease has been one of the major concerns recently. Around 45 million people
are suffering from this disease. Alzheimer's is a degenerative brain disease with an …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

The economic burden of dementia in low-and middle-income countries (LMICs): a systematic review

SM Mattap, D Mohan, AM McGrattan, P Allotey… - BMJ global …, 2022 - gh.bmj.com
Introduction More than two-thirds of people with dementia live in low-and middle-income
countries (LMICs), resulting in a significant economic burden in these settings. In this …

TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia

FL Yeh, Y Wang, I Tom, LC Gonzalez, M Sheng - Neuron, 2016 - cell.com
Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are
associated with Alzheimer's disease (AD). Starting from an unbiased protein microarray …