Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine

C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy

S Grisaru-Tal, ME Rothenberg, A Munitz - Nature immunology, 2022 - nature.com
Eosinophils are important effector cells and therapeutic targets in allergic diseases.
Emerging data indicate that eosinophils infiltrate a variety of solid tumor types and have …

EAACI molecular allergology user's guide 2.0

S Dramburg, C Hilger, AF Santos… - Pediatric Allergy and …, 2023 - Wiley Online Library
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

K Sacco, R Castagnoli, S Vakkilainen, C Liu… - Nature medicine, 2022 - nature.com
Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion

W Chen, S Chen, C Yan, Y Zhang, R Zhang… - Nature …, 2022 - nature.com
Abstract Interleukin-33 (IL-33), an epithelial cell-derived cytokine that responds rapidly to
environmental insult, has a critical role in initiating airway inflammatory diseases. However …

When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death

FJ Bock, JS Riley - Cell Death & Differentiation, 2023 - nature.com
Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion
to prevent negative consequences for the tissue or the organism. Dysfunctional apoptosis is …

Protease allergens as initiators–regulators of allergic inflammation

WT Soh, J Zhang, MD Hollenberg, H Vliagoftis… - Allergy, 2023 - Wiley Online Library
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …

[HTML][HTML] Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms

S Massironi, G Mulinacci, C Gallo, A Elvevi, S Danese… - Cells, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

Breaking down the complex pathophysiology of eosinophilic esophagitis

B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …

[HTML][HTML] The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

D Yazici, I Ogulur, Y Pat, H Babayev, E Barletta… - Seminars in …, 2023 - Elsevier
Since the 1960 s, our health has been compromised by exposure to over 350,000 newly
introduced toxic substances, contributing to the current pandemic in allergic, autoimmune …