Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …

Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

Recent empirical findings suggest that altered neural synchronization, which is
hypothesized to be associated with an imbalance of excitatory (E) and inhibitory (I) neuronal …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

There is now consistent evidence that neural oscillation at low‐and high‐frequencies
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …

Recent theoretical accounts have proposed excitation and inhibition (E/I) imbalance as a
possible mechanistic, network-level hypothesis underlying neural and behavioral …

The complexity and heterogeneity of schizophrenia symptoms challenge an objective
diagnosis, which is typically based on behavioral and clinical manifestations. Moreover, the …

Early detection and intervention in schizophrenia requires mechanism-based biomarkers
that capture neural circuitry dysfunction, allowing better patient stratification, monitoring of …

Background Diminished synaptic gain—the sensitivity of postsynaptic responses to neural
inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is …