Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Temperature is a critical environmental cue that controls the development and lifespan of
many animal species; however, mechanisms underlying low-temperature adaptation are …

During stress, global translation is reduced, but specific transcripts are actively translated.
How stress-responsive mRNAs are selectively translated is unknown. We show that METL-5 …

Animals must sense and acclimatize to environmental temperatures for survival, yet their
thermosensing mechanisms other than transient receptor potential (TRP) channels remain …

Tissue–tissue communications are integral to organismal aging, orchestrating a body-wide
aging process. The brain plays a key role in this process by detecting and processing …

Habituation is an adaptation seen in many organisms, defined by a reduction in the
response to repeated stimuli. Evolutionarily, habituation is thought to benefit the organism by …

Habituation represents a fundamental form of learning, yet the underlying molecular genetic
mechanisms are not well defined. Here we report on a genome-wide genetic screen …

How animals rewire cellular programs to survive cold is a fascinating problem with potential
biomedical implications, ranging from emergency medicine to space travel. Studying a …

Caenorhabditis elegans (C. elegans) exhibits cold tolerance and temperature
acclimatisation regulated by a small number of head sensory neurons, such as the ADL …