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Precision genome editing in the CRISPR era
J Salsman, G Dellaire - Biochemistry and cell biology, 2017 - cdnsciencepub.com
With the introduction of precision genome editing using CRISPR–Cas9 technology, we have
entered a new era of genetic engineering and gene therapy. With RNA-guided …
entered a new era of genetic engineering and gene therapy. With RNA-guided …
Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells
In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of
human in vitro models of neurological disease. The iPS-derived and differentiated cells …
human in vitro models of neurological disease. The iPS-derived and differentiated cells …
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
D Paquet, D Kwart, A Chen, A Sproul, S Jacob, S Teo… - Nature, 2016 - nature.com
The bacterial CRISPR/Cas9 system allows sequence-specific gene editing in many
organisms and holds promise as a tool to generate models of human diseases, for example …
organisms and holds promise as a tool to generate models of human diseases, for example …
A prudent path forward for genomic engineering and germline gene modification
Genome engineering technology offers unparalleled potential for modifying human and
nonhuman genomes. In humans, it holds the promise of curing genetic disease, while in …
nonhuman genomes. In humans, it holds the promise of curing genetic disease, while in …
RS-1 enhances CRISPR/Cas9-and TALEN-mediated knock-in efficiency
Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered
regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are …
regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are …
Defining the epoch we live in
Human alterations of Earth's environments are pervasive. Visible changes include the built
environment, conversion of forests and grasslands to agriculture, algal blooms, smog, and …
environment, conversion of forests and grasslands to agriculture, algal blooms, smog, and …
An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
The CRISPR/Cas9 system is a powerful genome editing tool and has been widely used for
biomedical research. However, many challenges, such as off-target effects and lack of easy …
biomedical research. However, many challenges, such as off-target effects and lack of easy …
Developmental chromatin programs determine oncogenic competence in melanoma
A Baggiolini, SJ Callahan, E Montal, JM Weiss, T Trieu… - Science, 2021 - science.org
INTRODUCTION Tumor analyses have shown that DNA mutations can transform cells in
some situations but not in others. In melanoma, BRAFV600E [serine/threonine-protein …
some situations but not in others. In melanoma, BRAFV600E [serine/threonine-protein …
TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells
Abstract TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC),
which can lead to DNA demethylation. However, direct connections between TET-mediated …
which can lead to DNA demethylation. However, direct connections between TET-mediated …
Antisense lncRNA transcription mediates DNA demethylation to drive stochastic protocadherin α promoter choice
Stochastic activation of clustered Protocadherin (Pcdh) α, β, and γ genes generates a cell-
surface identity code in individual neurons that functions in neural circuit assembly. Here, we …
surface identity code in individual neurons that functions in neural circuit assembly. Here, we …