Oxidative stress and hypertension
A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …
animal models of hypertension but remains elusive in humans. While initial studies focused …
NLRP3 inflammasome in endothelial dysfunction
B Bai, Y Yang, QI Wang, M Li, C Tian, Y Liu… - Cell death & …, 2020 - nature.com
Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate
immune signal receptors to sense pathogens and initiate inflammatory responses under …
immune signal receptors to sense pathogens and initiate inflammatory responses under …
Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets
Z Zhang, L Zhao, X Zhou, X Meng, X Zhou - Frontiers in immunology, 2023 - frontiersin.org
Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …
which have become a primary cause of death, and recent research has demonstrated that …
Targeting the NLRP3 inflammasome in severe COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
[HTML][HTML] Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
M Zhang, X Zhang, T Tian, Q Zhang, Y Wen, J Zhu… - Bioactive materials, 2022 - Elsevier
Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to
preventing gouty arthritis. However, colchicine, the most highly represented drug used in …
preventing gouty arthritis. However, colchicine, the most highly represented drug used in …
Immune mechanisms of hypertension
Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Hypertension: do inflammation and immunity hold the key to solving this epidemic?
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
Focus on the Role of NLRP3 Inflammasome in Diseases
Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …
Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain …
X Zhang, Y Li, P Yang, X Liu, L Lu, Y Chen… - … , and vascular biology, 2020 - Am Heart Assoc
Objectives: Vascular calcification is highly prevalent in patients with chronic kidney disease.
Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product …
Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product …
The role of inflammasomes in human diseases and their potential as therapeutic targets
J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …
signals and triggering the innate immune response. Each inflammasome complex has three …