Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Humans require a plethora of higher cognitive skills to perform executive functions, such as
reasoning, planning, language and social interactions, which are regulated predominantly …

The inquisitiveness about what happens in the brain has been there since the beginning of
humankind. Functional magnetic resonance imaging is a prominent tool which helps in the …

Neuroimaging has made it possible to measure pathological brain changes associated with
Alzheimer's disease (AD) in vivo. Over the past decade, these measures have been …

Early-onset Alzheimer's disease (EOAD) with onset< 65 years of age, while overshadowed
by the more common late-onset AD (LOAD), differs significantly from LOAD. EOAD …

Complex biological systems are organized across various spatiotemporal scales with
particular scientific disciplines dedicated to the study of each scale (eg genetics, molecular …

Alzheimer's disease (AD) is a neurodegenerative disease causing progressive cognitive
decline until eventual death. AD affects millions of individuals worldwide in the absence of …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

Alzheimer's disease is increasingly considered a large-scale network disconnection
syndrome, associated with progressive aggregation of pathological proteins, cortical …

Normal aging and Alzheimer's disease (AD) cause profound changes in the brain's structure
and function. AD in particular is accompanied by widespread cortical neuronal loss, and loss …