The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
New insights into the role of TREM2 in Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
M **, H Shiwaku, H Tanaka, T Obita, S Ohuchi… - Nature …, 2021 - nature.com
Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …
[HTML][HTML] Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …
Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis
Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …
of Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …
TREM2 function impedes tau seeding in neuritic plaques
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been
associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show …
associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show …
[HTML][HTML] TREM2 ectodomain and its soluble form in Alzheimer's disease
J Yang, Z Fu, X Zhang, M **ong, L Meng… - Journal of …, 2020 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed
on the surface of microglia. It mediates multiple pathophysiological processes in various …
on the surface of microglia. It mediates multiple pathophysiological processes in various …
[HTML][HTML] Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models
M Das, W Mao, Y Voskobiynyk, D Necula, I Lew… - Neurobiology of …, 2023 - Elsevier
The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases
the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed …
the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed …