From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview
Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational
and medicinal purposes. In many countries, cannabis‐based medicines have been …
and medicinal purposes. In many countries, cannabis‐based medicines have been …
DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling
TO Eichmann, A Lass - Cellular and Molecular Life Sciences, 2015 - Springer
The neutral lipids diacylglycerols (DAGs) are involved in a plethora of metabolic pathways.
They function as components of cellular membranes, as building blocks for glycero …
They function as components of cellular membranes, as building blocks for glycero …
The role of the endocannabinoid system in the brain–gut axis
The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-
arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of …
arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of …
Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
SM Brierley, B Greenwood-Van Meerveld… - Nature Reviews …, 2023 - nature.com
The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …
irritable bowel syndrome, presents a considerable clinical challenge, with few available …
Endocannabinoids in the Gut
NV DiPatrizio - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabis has been used medicinally for centuries to treat a variety of disorders, including
those associated with the gastrointestinal tract. The discovery of our bodies' own “cannabis …
those associated with the gastrointestinal tract. The discovery of our bodies' own “cannabis …
The gastrointestinal tract–a central organ of cannabinoid signaling in health and disease
Background In ancient medicine, extracts of the marijuana plant Cannabis sativa were used
against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of …
against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of …
Supporting gut health with medicinal cannabis in people with advanced cancer: potential benefits and challenges
The side effects of cancer therapy continue to cause significant health and cost burden to the
patient, their friends and family, and governments. A major barrier in the way in which these …
patient, their friends and family, and governments. A major barrier in the way in which these …
The microbiome and gut endocannabinoid system in the regulation of stress responses and metabolism
The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium
and enteroendocrine cells, and is able to modulate brain functions, both indirectly through …
and enteroendocrine cells, and is able to modulate brain functions, both indirectly through …