[HTML][HTML] Brain malignancies: Glioblastoma and brain metastases
Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies
Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells
Glioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor
microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM …
microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM …
The adaptive transition of glioblastoma stem cells and its implications on treatments
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
Patient-derived glioma models: from patients to dish to animals
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …
associated with a poor survival. Current standard of care consists of surgical resection …
Single-cell RNA sequencing in cancer: Applications, advances, and emerging challenges
G Sun, Z Li, D Rong, H Zhang, X Shi, W Yang… - Molecular Therapy …, 2021 - cell.com
Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …
urgently needed to further clarify the mechanisms of cancer so that better detection and …
Current trends in mouse models of glioblastoma
M Miyai, H Tomita, A Soeda, H Yano, T Iwama… - Journal of neuro …, 2017 - Springer
Glioblastoma is the most deadly brain tumor type and is characterized by a severe and high
rate of angiogenesis, remaining an incurable disease in the majority of cases. Mechanistic …
rate of angiogenesis, remaining an incurable disease in the majority of cases. Mechanistic …
Immunotherapy of glioblastoma: current strategies and challenges in tumor model development
Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …
immunotherapy is playing an increasingly central role in the treatment of many cancers …
Utility of glioblastoma patient-derived orthotopic xenografts in drug discovery and personalized therapy
M Patrizii, M Bartucci, SR Pine, HE Sabaawy - Frontiers in oncology, 2018 - frontiersin.org
Despite substantial effort and resources dedicated to drug discovery and development, new
anticancer agents often fail in clinical trials. Among many reasons, the lack of reliable …
anticancer agents often fail in clinical trials. Among many reasons, the lack of reliable …
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo
Glioblastoma multiforme is a universally lethal brain tumor that largely resists current
surgical and drug interventions. Despite important advancements in understanding GBM …
surgical and drug interventions. Despite important advancements in understanding GBM …