Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Fourteen ORFs have been identified in the severe acute respiratory syndrome-associated
coronavirus (SARS-CoV) genome. ORF 3a of SARS-CoV codes for a recently identified …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

The Shaker family of voltage-gated K+ channels has been thought of as an animal-specific
ion channel family that diversified in concert with nervous systems. It comprises four …

Objective Pathogenic variants in KCNB1, encoding the voltage‐gated potassium channel
KV2. 1, are associated with developmental and epileptic encephalopathy (DEE). Previous …

A proper rate of programmed cell death or apoptosis is required to maintain normal tissue
homeostasis. In disease states such as cancer and some forms of hypertension, apoptosis is …

Members of the Anoctamin (Ano)/TMEM16A family have recently been identified as
essential subunits of the Ca 2+-activated chloride channel (CaCC). For example, Ano1 is …

Chronic neuropathic pain affects millions of individuals worldwide, is typically long-lasting,
and remains poorly treated with existing therapies. Neuropathic pain arising from peripheral …

Electrically silent voltage-gated potassium (KvS) α-subunits do not form homotetramers but
heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in …