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Development and functional diversification of cortical interneurons
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …
collection of cell types that are characterized by their unique spatial and temporal …
The BRAIN initiative cell census consortium: lessons learned toward generating a comprehensive brain cell atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of
connectivity is critical for understanding the properties of neural circuits and how they …
connectivity is critical for understanding the properties of neural circuits and how they …
Molecular logic of cellular diversification in the mouse cerebral cortex
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …
generated during development through a series of temporally orchestrated events that are …
[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
Single-cell transcriptional diversity is a hallmark of developmental potential
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …
functionally distinct areas. To investigate the diversity of cell types across the mouse …
[HTML][HTML] Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
Developmental diversification of cortical inhibitory interneurons
Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …
investigate how this diversity is generated, here we used single-cell RNA sequencing to …
[HTML][HTML] The development and evolution of inhibitory neurons in primate cerebrum
Neuroanatomists have long speculated that expanded primate brains contain an increased
morphological diversity of inhibitory neurons (INs), and recent studies have identified …
morphological diversity of inhibitory neurons (INs), and recent studies have identified …
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
Understanding any brain circuit will require a categorization of its constituent neurons. In
hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to …
hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to …