Development and functional diversification of cortical interneurons

L Lim, D Mi, A Llorca, O Marín - Neuron, 2018 - cell.com
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

The BRAIN initiative cell census consortium: lessons learned toward generating a comprehensive brain cell atlas

JR Ecker, DH Geschwind, AR Kriegstein, J Ngai… - Neuron, 2017 - cell.com
A comprehensive characterization of neuronal cell types, their distributions, and patterns of
connectivity is critical for understanding the properties of neural circuits and how they …

Molecular logic of cellular diversification in the mouse cerebral cortex

DJ Di Bella, E Habibi, RR Stickels, G Scalia, J Brown… - Nature, 2021 - nature.com
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Z Yao, CTJ Van Velthoven, TN Nguyen, J Goldy… - Cell, 2021 - cell.com
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …

Single-cell transcriptional diversity is a hallmark of developmental potential

GS Gulati, SS Sikandar, DJ Wesche, A Manjunath… - Science, 2020 - science.org
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Shared and distinct transcriptomic cell types across neocortical areas

B Tasic, Z Yao, LT Graybuck, KA Smith, TN Nguyen… - Nature, 2018 - nature.com
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

[HTML][HTML] Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

D Franjic, M Skarica, S Ma, JI Arellano… - Neuron, 2022 - cell.com
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …

Developmental diversification of cortical inhibitory interneurons

C Mayer, C Hafemeister, RC Bandler, R Machold… - Nature, 2018 - nature.com
Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

[HTML][HTML] The development and evolution of inhibitory neurons in primate cerebrum

MT Schmitz, K Sandoval, CP Chen, MA Mostajo-Radji… - Nature, 2022 - nature.com
Neuroanatomists have long speculated that expanded primate brains contain an increased
morphological diversity of inhibitory neurons (INs), and recent studies have identified …

Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics

KD Harris, H Hochgerner, NG Skene, L Magno… - PLoS …, 2018 - journals.plos.org
Understanding any brain circuit will require a categorization of its constituent neurons. In
hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to …