[HTML][HTML] Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

G Marucci, M Buccioni, D Dal Ben, C Lambertucci… - …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …

Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress

Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

A perspective on multi-target drug discovery and design for complex diseases

RR Ramsay, MR Popovic-Nikolic, K Nikolic… - Clinical and translational …, 2018 - Springer
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …

Polypharmacology: challenges and opportunities in drug discovery: miniperspective

A Anighoro, J Bajorath, G Rastelli - Journal of medicinal chemistry, 2014 - ACS Publications
At present, the legendary magic bullet, ie, a drug with high potency and selectivity toward a
specific biological target, shares the spotlight with an emerging and alternative …

Multi-target design strategies for the improved treatment of Alzheimer's disease

P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …

Assessment of enzyme inhibition: a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs

RR Ramsay, KF Tipton - Molecules, 2017 - mdpi.com
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease

N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

Q Li, S He, Y Chen, F Feng, W Qu, H Sun - European journal of medicinal …, 2018 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …

The multifactorial nature of Alzheimer's disease for develo** potential therapeutics

M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Target enzyme in Alzheimer's disease: Acetylcholinesterase inhibitors

M Saxena, R Dubey - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Alzheimer's Disease (AD), affecting a large population worldwide is characterized by the
loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase …