Macrophages, as crucial cellular components of innate immunity, are characterized by
possessing high plasticity and an abnormal ability to differentiate in response to numerous …

Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

Objectives Bone defects caused by diseases and trauma are usually accompanied by
inflammation, and the implantation of biomaterials as a common repair method has also …

Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …

The disability, mortality and costs due to ionizing radiation (IR)-induced osteoporotic bone
fractures are substantial and no effective therapy exists. Ionizing radiation increases cellular …

Macrophages are crucial components of the immune system and play a critical role in the
initial defense against pathogens. They are highly heterogeneous and plastic and can be …

Targeting specific organs and cell types using nanotechnology and sophisticated delivery
methods has been at the forefront of applicative biomedical sciences lately. Macrophages …

Osteoporosis, characterized by compromised bone density and microarchitecture,
represents a significant global health challenge, particularly in aging populations. This …

During mechanical force-induced alveolar bone remodeling, macrophage-mediated local
inflammation plays a critical role. Yet, the detailed heterogeneity of macrophages is still …

Bone-metastatic prostate cancer is common in men with recurrent castrate-resistant disease.
To date, therapeutic focus has largely revolved around androgen deprivation therapy (ADT) …