Tumors arise from the transformation of normal stem cells or mature somatic cells.
Intriguingly, two types of tumors have been observed by pathologists for centuries: well …

Gametes undergo a specialized and reductional cell division termed meiosis. Female
gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the …

Chromosome segregation during meiosis in oocytes is error prone. The uniquely large
cytoplasmic size of oocytes, which provides support for embryogenesis after fertilization …

DNA methylation is one of the epigenetic mechanisms and plays important roles during
oogenesis and early embryo development in mammals. DNA methylation is basically known …

Mitochondrial thermogenesis is an adaptive response of cells to their surrounding stress.
Oxidative stress is one of the common stresses during in vitro maturation (IVM) of oocytes …

Glyphosate‐based herbicides (GBHs) are a group of widely used broad‐spectrum
agricultural pesticides. Due to the recalcitrance of GBH, it has been found in food and …

It is a well-known fact that the reproductive organs in women, especially oocytes, are
exposed to numerous regulatory pathways and environmental stimuli. The maternal age is …

The nucleolus is the largest substructure in the nucleus and forms around the nucleolar
organizer regions (NORs), which comprise hundreds of rRNA genes. Recent evidence …

The “life code” theory postulates that egg cells, which are giant, are the first cells in
reproduction and that damaged or aged giant somatic cells are the first cells in …

Meiotic maturation is a crucial step of oocyte formation, allowing its potential fertilization and
embryo development. Elucidating this process is important for both fundamental research …